The NAA leads and manages the national HIV and AIDS response by respecting strictly to the following guiding principles:
1. Law on prevention and control the HIV and AIDS epidemic in Cambodia
2. Government policy on poverty reduction
3. Government rectangular strategy
4. Ownership in leading and managing the response
5. Scientific evidence base
6. Efficient and cost effectiveness intervention
7. Universal access
8. Multi-sectoral and comprehensive response
9. Greater Involvement of People Living with or affected by HIV and AIDS (GIPA)
10. Human right base
11. Gender equality and equity